Cyclopamine (11-deoxojervine) of Hunan Sunfull Bio-tech Co., Ltd.
Botanical Resource: Veratrum californicum or Veratrum nigrum L
Molecular formula: C27H41NO2
Molecular weight: 411.62
CAS No.: 4449-51-8
Melting point: 237-238ºC
Specific optical Rotation: [α]20ºCD -44.2º
Product Spec.:
98% Cyclopamine (11-deoxojervine)
Molecular Structure
Product Introduction
Cyclopamine (11-deoxojervine) is a naturally-occurring chemical that belongs to the group of steroidal jerveratrum alkaloids. It is a teratogen isolated from the corn lily (Veratrum californicum) that causes usually fatal birth defects. It can prevent the fetal brain from dividing into two lobes (holoprosencephaly) and cause the development of a single eye (cyclopia). It does so by suppressing the hedgehog gene (Hh). Cyclopamine is useful in studying the role of Hh in normal development, and as a potential treatment for certain cancers in which Hh is overexpressed.
Physical Properties:
White Powder; Odorless; Melting point:237-238ºC; Solubility:5mg·ml-1 Methanol;10mg·ml-1DMF.
Loss on drying: ≤0.5%
Physiological Functions & Applications
Cyclopamine inhibits the hedgehog signaling pathway (Hh) by influencing the balance between the active and inactive forms of the Smoothened protein.Cyclopamine is currently being investigated as a treatment agent in basal cell carcinoma, medulloblastoma, and rhabdomyosarcoma, tumors that result from excessive Hh activity [2], glioblastoma, and as a treatment agent for multiple myeloma.
HPLC-ELSD Chromatogram of 98% Cyclopamine
LC-MS of cyclopamine
H1-NMR of cyclopamine in CDCI3
C13-NMR of cyclopamine in CDCI3
Company Introduction
HUNAN SUNFULL BIO-TECH Co., Ltd., certified with ISO9001, ISO22000, Kosher, HALAL & HACCP, and specialized in the R&D, production and marketing of high value green tea and botanical extracts for dietary supplement, beverages, cosmetics & pharmaceuticals. We're the global leading manufacturer of green tea EGCG, (-)-Epicatechin, L-theanine, Theaflavins & Tea Polysacchrides. Our key botanical extracts including Aronia extract, Broccoli extract (Sulforaphane), Ginseng extract, Luo han guo extract, Maca extract, Milk thistle extract, etc. And many APIs (Amygdalin, Magnolol, Polydatin, Resveratrol, Sanguinarine, Swertiamarin, etc. ) Our products have been enjoying great popularity in the world markets due to their superior quality and competitive prices. SUNFULL also has becoming the 1st choice of natural ingredientsto many global famous enterprises and their most important strategic partner in China.
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