Supply Cyclopamine (11-deoxojervine) as a Treatment Agent for Multiple Myeloma.

• Powder: Yes
• Customized: Customized
• Certification: ISO 9001, Kosher/ Sc/Halal
• State: Powder
• Purity: >98%
• CAS No.: 4449-51-8
• Model NO.: SF-CYC90
• Molecular Weight: 411.62
• Melting Point: 237-238ºC
• Transport Package: Pack in Paper-Drums and Two Plastic-Bags Inside.
• Specification: 98% Cyclopamine (11-deoxojervine)
• Origin: P. R. China
• Production Capacity: 20 Ton/Tons Per Year

Product Description

                Cyclopamine (11-deoxojervine)


      

Botanical Resource:              Veratrum californicum or Veratrum nigrum L
CAS No.:                                 4449-51-8
Molecular formula:                C₂₇H₄₁NO₂
Molecular weight:                   411.62
Melting point:                         237-238ºC
Specific optical Rotation:      [α]^20ºC_D  -44.2º
Product Specification            98% Cyclopamine (11-deoxojervine)
 

Product Name	Cyclopamine	Country of Origin()	P. R. China
Specification	98%Cyclopamine	CAS No()	4449-51-8
Latin Name	Veratrum nigrum L	Active Ingredient Markers	Cyclopamine

Analysis Items	Specifications	Test Methods
Description
Identification	Positive	TLC
Appearance & Color	White powder	Visual
Odor & Taste	Characteristic	Organoleptic
Mesh Size	NLT 90% through 80 mesh	80 Mesh screen
Solubility	Good solubility in hydro-alcoholic solution	Visual
Extract Solvent	Grain alcohol and water	/
Excipient	None	/

Product Introduction
Cyclopamine (11-deoxojervine) is a naturally-occurring chemical that belongs to the group of steroidal jerveratrum alkaloids. It is a teratogen isolated from the corn lily (Veratrum californicum) that causes usually fatal birth defects. It can prevent the fetal brain from dividing into two lobes (holoprosencephaly) and cause the development of a single eye (cyclopia). It does so by suppressing the hedgehog gene (Hh). Cyclopamine is useful in studying the role of Hh in normal development, and as a potential treatment for certain cancers in which Hh is overexpressed.

Physical Properties:      
White Powder; Odorless; Melting point:237-238ºC; Solubility:5mg·ml-1 Methanol;10mg·ml-1DMF.
Loss on drying:  ≤0.5% 

Physiological Functions & Applications
Cyclopamine inhibits the hedgehog signaling pathway (Hh) by influencing the balance between the active and inactive forms of the Smoothened protein.Cyclopamine is currently being investigated as a treatment agent in basal cell carcinoma, medulloblastoma, and rhabdomyosarcoma, tumors that result from excessive Hh activity [2], glioblastoma, and as a treatment agent for multiple myeloma.
  

Packing: Pack in paper drum and plastic-bags inside,Net Weight :25Kg/drum

Company Information

HUNAN SUNFULL BIO-TECH CO., LTD., certified with ISO9001, ISO22000, Kosher, HALAL & HACCP, and specialized in the R&D, production and marketing of high value green tea and botanical extracts for dietary supplement, beverages, cosmetics & pharmaceuticals. We're the global leading manufacturer of Green tea EGCG, (-)-Epicatechin, L-theanine, Theaflavins & Tea polyphenols.Our key botanical extracts including Aronia extract,Ginseng extract, etc. and many APIs (Gentiana Extract, Hibiscus Flower Extract,Swertiamarin, Paeonia Extract,Vine Tea Extractetc.) Our products have been enjoying great popularity in the world markets
due to their superior quality and competitive prices. SUNFULL also has becoming the 1st choice of natural ingredientsto many global famous enterprises and their most important strategic partner in China.

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